Current Evidence of Platelet-Rich Blood Plasma for Pelvic Organ Prolapse: A Review

Edy Fakhrizal; Arya Marganda Simanjuntak; Anastasya Hutapea

doi:10.24198/obgynia.v6i3.530

Current Evidence of Platelet-Rich Blood Plasma for Pelvic Organ Prolapse: A Review

Edy Fakhrizal, Arya Marganda Simanjuntak, Anastasya Hutapea

Abstract

Objective: To review the current evidence of the potential use of Platelet-Rich Plasma (PRP) in the field of urogynecology, especially in POP cases.
Method: This review used several databases (Google Scholar, Pubmed, and Science Direct) and searched for English and Indonesian articles in the last ten years. Articles were received in the form of case reports, observational studies and clinical trials that discussed the use of Platelet-Rich Plasma in cases of Pelvic Organ Prolapse (POP).
Results: A total of three articles were included in this review.
Discussion: There were two patient studies and one in vitro study. The POP patient study showed favorable results with low recurrence rates in patients who received Platelet Rich-Plasma compared to those who did not and another study that conducted a one-year evaluation found no recurrences after the patients received Platelet Rich Plasma at the surgical site. The in vitro study showed good cell attachment and proliferation in vaginal tissue biopsies with Platelet-Rich Plasma applied to the tissue.
Conclusion: Platelet-Rich Plasma may promote tissue regeneration, hence potentially reduce recurrency after reconstruction.

Bukti Terkini Plasma Darah Kaya Trombosit untuk Prolaps Organ Panggul: Sebuah Kajian

Tujuan: Untuk meninjau bukti terkini mengenai potensi penggunaan Platelet-Rich Plasma di bidang uroginekologi, khususnya pada kasus POP.
Metode:Tinjauan ini menggunakan beberapa database Google Scholar, Pubmed, dan Science Direct) dan mencari artikel berbahasa Inggris dan Indonesia dalam sepuluh tahun terakhir. Artikel yang diterima berupa laporan kasus, studi observasional, dan uji klinis yang membahas penggunaan Platelet-Rich Plasma pada kasus Prolaps Organ Panggul (POP).
Hasil: Sebanyak tiga artikel termasuk dalam tinjauan ini.
Diskusi: Terdapat dua studi pasien dan satu studi in vitro. Studi pasien POP menunjukkan hasil yang baik dengan tingkat kekambuhan yang rendah pada pasien yang menerima PRP dibandingkan dengan mereka yang tidak menerima Platelet-Rich Plasma dan studi lain yang melakukan evaluasi satu tahun tidak menemukan adanya kekambuhan setelah pasien menerima Platelet-Rich Plasma di tempat pembedahan. Studi in vitro menunjukkan perlekatan dan proliferasi sel yang baik pada biopsi jaringan vagina dengan Platelet-Rich Plasma yang diaplikasikan pada jaringan tersebut.
Kesimpulan: Platelet-Rich Plasma dapat meningkatkan regenerasi jaringan, sehingga berpotensi mengurangi kekambuhan setelah rekonstruksi.

Kata kunci: Platelet-Rich Blood Plasma, Prolaps Organ Panggul, Uroginekologi

Keywords

Pelvic Organ Prolapse; Platelet-Rich Blood Plasma; Urogynecology

Full Text:

PDF

References

Prawirohardjo S. Ilmu Kandungan. Anwar M, Baziad A, Prabowo RP, editors. P.T. Bina Pustaka Sarwono Prawirohardjo; 2011.

Wang B, Chen Y, Zhu X, Wang T, Li M, Huang Y, et al. Global burden and trends of pelvic organ prolapse associated with aging women: An observational trend study from 1990 to 2019. Front Public Health. 2022;10:975829.

Barber MD, Maher C. Epidemiology and outcome assessment of pelvic organ prolapse. Int Urogynecol J. 2013 Nov;24(11):1783–90.

Fakhrizal E. Prolaps Organ Panggul. 1st ed. Pekanbaru: Taman Karya; 2021.

Kayondo M, Geissbüehler V, Migisha R, Kajabwangu R, Njagi J, Kato PK, et al. Risk factors for recurrence of pelvic organ prolapse after vaginal surgery among Ugandan women: a prospective cohort study. Int Urogynecol J. 2022 Jul;33(7):1933–9.

Chrysanthopoulou EL, Pergialiotis V, Perrea D, Κourkoulis S, Verikokos C, Doumouchtsis SK. Platelet rich plasma as a minimally invasive approach to uterine prolapse. Med Hypotheses. 2017 Jul;104:97–100.

Castellani D, Valloni A, Piccirilli A, Paradiso Galatioto G, Vicentini C. An innovative approach to treating vaginal mesh exposure after abdominal sacral colpopexy: endoscopic resection of mesh and platelet-rich plasma; initial experience in three women. Int Urogynecol J. 2017 Feb;28(2):325–7.

Medel S, Alarab M, Kufaishi H, Drutz H, Shynlova O. Attachment of Primary Vaginal Fibroblasts to Absorbable and Nonabsorbable Implant Materials Coated With Platelet-Rich Plasma: Potential Application in Pelvic Organ Prolapse Surgery. Female Pelvic Med Reconstr Surg. 2015;21(4):190–7.

Atılgan AE, Aydın A. Cystocele Repair with Platelet-Rich Plasma. Indian Journal of Surgery. 2021 Jun 19;83(3):726–30.

Pochini A de C, Antonioli E, Bucci DZ, Sardinha LR, Andreoli CV, Ferretti M, et al. Analysis of cytokine profile and growth factors in platelet-rich plasma obtained by open systems and commercial columns. Einstein (Sao Paulo). 2016 Jul 1;14(3):391–7.

Le ADK, Enweze L, DeBaun MR, Dragoo JL. Platelet-Rich Plasma. Vol. 38, Clinics in Sports Medicine. W.B. Saunders; 2019. p. 17–44.

Sánchez M, Anitua E, Delgado D, Sanchez P, Prado R, Orive G, et al. Platelet-rich plasma, a source of autologous growth factors and biomimetic scaffold for peripheral nerve regeneration. Vol. 17, Expert Opinion on Biological Therapy. Taylor and Francis Ltd; 2017. p. 197–212.

Everts P, Onishi K, Jayaram P, Lana JF, Mautner K. Platelet-rich plasma: New performance understandings and therapeutic considerations in 2020. Vol. 21, International Journal of Molecular Sciences. MDPI AG; 2020. p. 1–36.

Padilla S, Sánchez M, Orive G, Anitua E. Human-Based Biological and Biomimetic Autologous Therapies for Musculoskeletal Tissue Regeneration. Vol. 35, Trends in Biotechnology. Elsevier Ltd; 2017. p. 192–202.

Liu X, Wang L, Ma C, Wang G, Zhang Y, Sun S. Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway. J Orthop Surg Res. 2019 Dec 30;14(1).

Guo SC, Tao SC, Yin WJ, Qi X, Yuan T, Zhang CQ. Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model. Theranostics. 2017;7(1):81–96.

Lana JF, Macedo A, Ingrao ILG, Huber SC, Santos GS, Santana MHA. Leukocyte-rich PRP for knee osteoarthritis: Current concepts. Vol. 10, Journal of Clinical Orthopaedics and Trauma. Elsevier B.V.; 2019. p. S179–82.

Cecerska-Heryć E, Goszka M, Serwin N, Roszak M, Grygorcewicz B, Heryć R, et al. Applications of the regenerative capacity of platelets in modern medicine. Cytokine Growth Factor Rev. 2022 Apr;64:84–94.

Ramaswamy Reddy SH, Reddy R, Babu NC, Ashok GN. Stem-cell therapy and platelet-rich plasma in regenerative medicines: A review on pros and cons of the technologies. J Oral Maxillofac Pathol. 2018;22(3):367–74.

Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009 Mar;27(3):158–67.

Guevara-Alvarez A, Schmitt A, Russell RP, Imhoff AB, Buchmann S. Growth factor delivery vehicles for tendon injuries: Mesenchymal stem cells and Platelet Rich Plasma. Muscles Ligaments Tendons J. 2014 Jul;4(3):378–85.

Oklu R, Walker TG, Wicky S, Hesketh R. Angiogenesis and current antiangiogenic strategies for the treatment of cancer. J Vasc Interv Radiol. 2010 Dec;21(12):1791–805; quiz 1806.

Martínez CE, Smith PC, Palma Alvarado VA. The influence of platelet-derived products on angiogenesis and tissue repair: a concise update. Front Physiol. 2015;6:290.

El-Sharkawy H, Kantarci A, Deady J, Hasturk H, Liu H, Alshahat M, et al. Platelet-Rich Plasma: Growth Factors and Pro- and Anti-Inflammatory Properties. J Periodontol. 2007 Apr;78(4):661–9.

Jain NK, Gulati M. Platelet-rich plasma: a healing virtuoso. Blood Res. 2016;51(1):3.

Nikolopoulos KI, Pergialiotis V, Perrea D, Doumouchtsis SK. Restoration of the pubourethral ligament with platelet rich plasma for the treatment of stress urinary incontinence. Med Hypotheses. 2016 May;90:29–31.

Alsousou J, Ali A, Willett K, Harrison P. The role of platelet-rich plasma in tissue regeneration. Platelets. 2013;24(3):173–82.

Paichitrojjana A, Paichitrojjana A. Platelet Rich Plasma and Its Use in Hair Regrowth: A Review. Drug Des Devel Ther. 2022;16:635–45.

Akbarzadeh S, McKenzie MB, Rahman MM, Cleland H. Allogeneic Platelet-Rich Plasma: Is It Safe and Effective for Wound Repair? Eur Surg Res. 2021;62(1):1–9.

Semenič D, Cirman T, Rožman P, Smrke DM. REGENERATION OF CHRONIC WOUNDS WITH ALLOGENEIC PLATELET GEL VERSUS HYDROGEL TREATMENT: A PROSPECTIVE STUDY. Acta Clin Croat. 2018 Sep;57(3):434–42.

DOI: http://dx.doi.org/10.24198/obgynia.v6i3.530